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Monday, April 22, 2013
Apple Has Reportedly Rejected Up to 8 Million iPhones Delivered By Foxconn
Saturday, April 20, 2013
Brando Power Jacket for Nokia Lumia 920 ? 2200mAh review
The Power Jacket for Nokia Lumia 920?from Brando is an extended battery/case that can nearly double the battery life for the Lumia 920, if you’re willing to accept the trade-offs that come with it. ?So what are the trade-offs? ?Let’s look at them. Unboxed Besides the nearly impossible to photograph black version I received above, [...]
Source: http://the-gadgeteer.com/2013/04/19/brando-power-jacket-for-nokia-lumia-920-2200mah-review/
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Novel monoclonal antibody inhibits tumor growth in breast cancer and angiosarcoma
Apr. 19, 2013 ? A monoclonal antibody targeting a protein known as SFPR2 has been shown by researchers at the University of North Carolina to inhibit tumor growth in pre-clinical models of breast cancer and angiosarcoma.
In a paper published in the April 19 issue of Molecular Cancer Therapeutics, a team led by Nancy Klauber-DeMore, MD, Professor of surgery and a member of UNC Lineberger Comprehensive Cancer Center, used a monoclonal antibody to target SFRP2 expressed in cells from triple-negative breast cancer and the aggressive blood-vessel malignancy angiosarcoma, reducing the rate of tumor growth. The antibody, created at the University of North Carolina, is the first therapeutic discovered that targets SFRP2.
"We showed in this paper that targeting SFRP2 with a monoclonal antibody in pre-clinical models inhibits tumor growth. This demonstrates that SFRP2 is a therapeutic target for cancer" said Dr. DeMore.
The DeMore lab first discovered the role of SFRP2 in tumor growth while looking to develop an alternative to the FDA-approved anti-angiogenesis drug known as Avastin (bevacizumab). Avastin targets the protein VEGF, which has also been tied to angiogenesis (the production of new blood vessels). Although Avastin is of benefit to some patients with cancer, not all tumors respond to Avastin, and of those that respond, some eventually progress. To find a solution for patients whose tumors are resistant to Avastin, DeMore began looking at other proteins linked to angiogenesis that could be used as therapeutic targets.
"We previously microdissected blood vessels from malignant human breast cancers and compared gene expression to blood vessels microdissected from normal tissue. We found a number of genes that were highly over-expressed in the malignant blood vessels compared to normal. One of those genes was SFRP2," said Dr. DeMore.
The DeMore lab found that SFRP2 is expressed in a variety of human cancers, including breast, prostate, lung, pancreas, ovarian, colon, kidney tumors, and angiosarcomas, DeMore, working with Dr. Cam Patterson, Ernest and Hazel Craige Distinguished Professor of Cardiovascular Medicine, discovered that SFRP2 acted as a potent stimulator of angiogenesis, leading their team to hypothesize that targeting SFRP2 could inhibit tumor growth. In collaboration with Dr. Russ Mumper, the John A. McNeill Distinguished Professor in the Division of Molecular Pharmaceutics, their group developed a drug to target SFRP2.
"Demonstrating that a monoclonal antibody to SFRP2 inhibits tumor growth in pre-clinical models opens up a new potential for drug development. This treatment is not presently available for human studies, but our efforts are focused on obtaining funding for further drug development that would lead to a clinical trial" said DeMore.
This work was supported by National Institute of Health (P50-CA58223, 1R01CA142657-01A1 and R01 HL61656), North Carolina TraCS Large Pilot Award, University Cancer Research Fund, Nancy DeMore Foundation and North Carolina Kickstart Commercialization Collaboration Award.
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Journal Reference:
- Emily Fontenot, Emma Rossi, Russell Mumper, Stephanie Snyder, Sharareh Siamakpour-Reihani, Ping Ma, Eleanor Hilliard, Bradley Bone, David Ketelsen, Charlene Santos, Cam Patterson, and Nancy Klauber-DeMore. A Novel Monoclonal Antibody to Secreted Frizzled-Related Protein 2 Inhibits Tumor Growth. Molecular Cancer Therapeutics, April 19, 2013 DOI: 10.1158/1535-7163.MCT-12-1066
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/7dVeURnp7fM/130419132516.htm
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Friday, April 19, 2013
U.S. conductor becomes first woman to lead Proms finale
By Shadia Nasralla
LONDON (Reuters) - American conductor Marin Alsop is to become the first woman in 118 years to lead the Last Night of the Proms, the grand finale of Britain's leading classical music festival which includes a punk band and gospel choirs in its line-up.
Details of the 2013 BBC Proms were unveiled on Thursday, with the festival involving 92 concerts over two months to appeal to a wide audience with chamber music, TV theme tunes, gospel choirs and punk veterans The Stranglers set to perform.
The festival will open on July 12 with Sakari Oramo conducting the First Night of the Proms as he starts his tenure as chief conductor of the BBC Symphony Orchestra.
It closes on September 7 with American mezzo-soprano Joyce DiDonato and British violinist Nigel Kennedy conducted by Alsop, 56, the chief conductor of the Sao Paulo Symphony Orchestra and music director of the Baltimore Symphony Orchestra.
Roger Wright, director of the Proms, said Alsop was ideal.
"We don't plan any demographic. We chose her because she's a really good conductor and she'll make a great conductor on the last night," Wright told a news conference.
The Last Night of the Proms, broadcast globally, will feature pieces by Richard Wagner and Gioachino Rossini and, in line with tradition, end with the rousing trio of "Rule, Britannia", "Pomp and Circumstance" and "Jerusalem" as the audience wave flags.
In past years, hundreds of fans have queued for hours, and even overnight, outside London's cavernous Royal Albert Hall to get hold of the coveted "promming tickets" that grant a standing place in front of the stage for as little as 5 pounds.
Highlights of the 2013 Proms include Israeli Daniel Barenboim conducting Wagner's complete four opera "Ring Cycle" and Vivaldi's "The Four Seasons" played by genre-crossing violinist Kennedy.
PUNK TO PERCUSSION
Giuseppe Verdi's 200th birthday will be marked with performances by Maltese tenor Joseph Calleja, soprano Kristine Opolais, and Italian orchestras from Rome and Milan.
Two evenings dedicated to music from the BBC's popular sci-fi TV drama "Dr Who", which is celebrating its 50th anniversary this year, and a Hollywood Rhapsody evening of Golden Age film music are set to attract non-classical fans.
Rap and soul will clash with orchestral showpieces as conductor Jules Buckley brings together urban artists with the BBC Symphony Orchestra in an evening featuring popular British singer Laura Mvula.
The Stranglers, known for songs "Golden Brown" and "No More Heroes", will perform with the London Sinfonietta.
The Proms will also give a platform for artists from Azerbaijan and Mali as well as Grammy Award-winning Touraeg guitar group Tinariwen that started out in Algeria.
Wright said broadening the appeal of the Proms was important even though the focus remained on the Western classical canon.
"If you can develop and get people into what can for some be a forbidding hall, or can look like a forbidding hall, then that's part of what the Proms' job has been since 1895," he said.
Apart from performances by various BBC orchestras, there will be appearances from top international orchestras including the Vienna Philharmonic, Olso Philharmonic, and the Bavarian Radio Symphony Orchestra.
Freshly inaugurated this year, the U.S.'s National Youth Orchestra will mark its first time in Europe with a performance at the Proms including star violinist Joshua Bell.
At the first free main evening Prom, the National Youth Orchestra of Britain will celebrate young artists at the festival with Beethoven's Symphony No. 9.
"It is in a way madness to put Beethoven 9 on at the Proms and make it free. ... it's all part of our desire to broaden the audience," Wright said.
Tickets for the Proms go on sale from May 11.
(Reporting By Shadia Nasralla, Editing by Belinda Goldsmith)
Source: http://news.yahoo.com/us-conductor-becomes-first-woman-lead-britains-proms-150251034.html
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Secrets To Quit Smoking And Kick Your Habit | Everything You Need ...
Tobacco freedom is definitely an aspiration on most smokers, and yet also something that smokers attempt to obtain and fail at again and again. In the event that you smoke and have struggled in the past with putting them down permanently, keep reading. The next sentences contain proven factors from those people who have succeeded.
Find yet another way to flake out. Nicotine is really a relaxant, which means you have to look for a substitute to lessen your stress. A massage or yoga is just a really good way of soothing, or you could attempt a hot bath, or playing your favorite music. Whenever feasible, try to avoid something tense during the initial couple of weeks once you give up smoking.
Realize that the very first day or two are the hardest, if you?re attempting to stop smoking. As soon as you get past the physical withdrawal signs, which last around three days, the worst element of quitting has ended. You?ll still experience some psychological withdrawal symptoms and intense desires, but in general, stopping gets easier as time passes.
You should seek out support in your neighborhood. While on the web support is great, face-to-face support will help you relearn how exactly to socialize without tobacco. Cigarette cessation support groups are wonderful places to do that, as it pertains to quitting smoking as your unique emotional challenges will be there understood by the people.
Plan a regular exercise routine. Exercising provides you with a healthy and positive focus for the life. Additionally, it may replace cigarettes in your head. You will be less likely to want to smoke again, as physical fitness is gained by you. Try to exercise at least five times weekly for best results.
Confer with your doctor about prescription medications. If you?d like to ease nicotine withdrawal symptoms, consider prescription drugs. There are certain drugs that influence the chemical balance in the human brain and might help reduce cravings. Additionally, there are drugs that may reduce bothersome withdrawal indicators, like inability to concentrate or depression.
With a couple form of nicotine replacement is a good way to slowly ease your addiction to smoking when you are attempting to quit. Smoking substitutes come in many forms, including lozenges, gum, and patches that may be worn on the body. These products give your system a little dose of cravings are eased by nicotine, which for using tobacco products.
If you have made a decision to quit smoking, mentally get ready for what is ahead. Try to concentrate on the fact that you are able to stop, and that this isn?t an impossible dream. Set an official ?quit date? and also consider putting it to your calendar. By taking this type of positive approach, your likelihood of stopping increase.
Don?t be concerned about being great. Many people who quit smoking have to make a few attempts at it before they succeed. If you are it is made by one of the lucky few who on your own first try; congratulations. For the others of you, beating yourself up over it can only strain you out and cause stronger desires to smoke. Relax and do the best you can.
Each time when you?re trying to stop smoking you feel like smoking, reward your self for perhaps not carrying it out. Put that money sideways, if you feel like you are about to go buy a pack of cigarettes. Get yourself something nice that tells you of your success, after you do this for some time.
Prevent holding your cigarettes around with you. This makes them harder to make the journey to and you will manage to reduce smoking by doing this. Once they are an inconvenience to make it to, they will not be smoked by you as often. This will ultimately allow you to quit smoking for good.
Don?t feel that a nicotine withdrawal treatment has to have nicotine in it. While it is true that you can find an alternative source of nicotine and reduce your levels of it, you could just get one of these prescription drugs that blocks your dependence on nicotine. Consult your personal doctor about a medicine that may just kill your desires.
Set a certain date for you to stop smoking, and tell everyone else you know very well what this date will be. It?ll create a sense of accountability on your part, the one that you will be ashamed never to continue with. You will be observed as failing or a person who can?t control their actions. Furthermore, those around you will help you leave, if you give them the opportunity to do this.
Ensure your stress is reduced by you as much as possible when you are wanting to quit smoking. If they are under great pressure as the smoking helps them to relax many individuals turn to smoking. Listen to some relaxing music, obtain a massage, choose a walk. Do whatever helps stress to be relieved by you.
Keep at heart that there surely is just one outcome from taking another puff of a cigarette. That consequence is smoking again at the particular level you are in a healthcare facility dying and that you were at, before behavior cripples you. It is a scary fact that will assist you stick to track.
Create a step-by-step listing of goals and rewards. Give a limited date to yourself of which you intend to be achieved smoking completely, and split the full time between then and now with smaller targets. Add a desirable and very particular (however feasible) incentive to each one of these goals to keep yourself stoked up about quitting.
Where people generally smoke to avoid temptation try to avoid areas. Avoid smoking areas at bars, smoking rooms at other and work places where there are smokers, if you think the temptation could be too much. Also, when meeting friends or family that smoke, make an effort to do this in a smoke-free atmosphere, such as for example, non-smoking restaurants and parks.
Since you arrive at the end with this report, you have read ideas and insights provided by others. They are people who once smoked, just like you do now, but don?t smoke any more, like you hope to be. Follow their some ideas and you?ll soon follow in their achievement.Steve Miller
BestElectronicCigaretteSource.net
575 Market Street, Suite 3000
San Francisco, CA 94105
(415) 209-5257
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Regional Food & Drink? | United States Forum | Fodor's Travel Talk ...
No, no, no, Doug! An onion burger isn't even a little bit like a White Castle, and, yes, it is classically limited to the El Reno (just west of OKC) area.
In the first place, it's BIG. Three times as big as White Castle, maybe four. In the second place, it is a loose (almost loose enough to see through) patty of meat, almost like you chopped it quickly off the end of a package of ground beef to make chili but slapped it on the grill instead. Then it is fried on the [greasy] hot top separately from the onions. They are combined on a greasy hot bun when finished and served -- now, Easterners, remain calm -- with your choice of ketchup or yellow mustard. Mustard goes on hot dogs! Not always.
There is a fair amount of other stuff to see in El Reno, and if you space your eating, you can have an onion burger at each of the three classic places. I had potato salads rather than fries with mine, IIRC.
Source: http://www.fodors.com/community/united-states/regional-food-drink.cfm
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Thursday, April 18, 2013
Distant blazar is a high-energy astrophysics puzzle
![[ Back to EurekAlert! ]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_stzeRqULnRwlOB48BueCBfjKRWsZJ_0FZN1VK_QAFw-C6T11J1YW3EZZ65-k07-1nrxc_Po_dmWCkK3JyTRFmH2fZ6ea59wTnsxyMzBpY=s0-d){kind=small}
Public release date: 18-Apr-2013[ | E-mail |
Share ] Contact: Tim Stephens
stephens@ucsc.edu
831-459-2495
University of California - Santa Cruz
Blazar PKS 1424+240 is the most distant known source of very high-energy gamma rays, but emission spectrum deviates from expectations
Blazars are the brightest of active galactic nuclei, and many emit very high-energy gamma rays. New observations of the blazar known as PKS 1424+240 show that it is the most distant known source of very high-energy gamma rays, but its emission spectrum now appears highly unusual in light of the new data.
A team led by physicists at the University of California, Santa Cruz, used data from the Hubble Space Telescope to set a lower limit for the blazar's redshift (z ? 0.6035), which corresponds to a distance of at least 7.4 billion light-years. Over such a great distance, a substantial proportion of the gamma rays should be absorbed by the extragalactic background light, but calculations that account for the expected absorption yield an unexpected emission spectrum for the blazar.
"We're seeing an extraordinarily bright source which does not display the characteristic emission expected from a very high-energy blazar," said Amy Furniss, a graduate student at the Santa Cruz Institute for Particle Physics (SCIPP) at UCSC and first author of a paper describing the new findings. The paper has been accepted for publication in Astrophysical Journal Letters and is currently posted on arXiv.org.
Coauthor David Williams, adjunct professor of physics at UC Santa Cruz, said the findings may indicate something new about the emission mechanisms of blazars, the extragalactic background light, or the propagation of gamma-ray photons over long distances.
"We're finding very high-energy gamma-ray sources at greater distances than we thought we might, and in doing so we're finding some things we don't entirely understand," Williams said. "Having a source at this distance will allow us to better understand how much background absorption there is and test the cosmological models that predict the extragalactic background light."
The extragalactic background light (EBL) is the diffuse radiation from all stars and galaxies, a dim but pervasive glow that fills the universe. When a high-energy gamma-ray photon collides with a lower-energy EBL photon, they annihilate and create an electron-positron pair. The farther gamma rays have to travel the more likely they are to be absorbed by this mechanism. This limits the distance to which sources of very high-energy gamma rays can be detected.
Measuring the EBL is extremely difficult because there are so many bright sources of light in our immediate neighborhood. In addition to estimates based on cosmological models, astronomers have used galaxy counts to set a lower limit for the EBL. Using a model close to this lower limit to calculate the expected absorption of very high-energy gamma rays from PKS 1424+240, Furniss derived an intrinsic gamma-ray emission spectrum for the blazar. The results, however, deviate from the expected emission based on current blazar models.
Blazar emission is thought to result from a relativistic jet of particles powered by matter falling onto a supermassive black hole at the center of the host galaxy. "There may be something going on in the emission mechanisms of the blazar that we don't understand," Williams said. "There are more exotic explanations as well, but it may be premature to speculate at this point."
Gamma rays from PKS 1424+240 were first detected by the Fermi Gamma-ray Space Telescope and subsequently by the ground-based instrument VERITAS (Very Energetic Radiation Imaging Telescope Array System), which is sensitive to gamma-rays in the very high-energy (VHE) band from about 100 GeV to more than 10 TeV. To determine the redshift of the blazar--a measure of how much the light from an object has been stretched to longer wavelengths by the expansion of the universe--the researchers used data obtained by the Hubble Space Telescope's Cosmic Origins Spectrograph for another research program.
###
In addition to Furniss and Williams, the coauthors of the paper include J. Xavier Prochaska, professor of astronomy and astrophysics at UCSC; Joel Primack, professor of physics at UCSC; Michele Fumagalli, a former UCSC graduate student now at Carnegie Observatories and Princeton University; Charles Danforth and John Stocke at the University of Colorado; Meg Urry at Yale University; Alex Filippenko at UC Berkeley; and William Neely at the NF/ Observatory.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 18-Apr-2013[ | E-mail |
Share ] Contact: Tim Stephens
stephens@ucsc.edu
831-459-2495
University of California - Santa Cruz
Blazar PKS 1424+240 is the most distant known source of very high-energy gamma rays, but emission spectrum deviates from expectations
Blazars are the brightest of active galactic nuclei, and many emit very high-energy gamma rays. New observations of the blazar known as PKS 1424+240 show that it is the most distant known source of very high-energy gamma rays, but its emission spectrum now appears highly unusual in light of the new data.
A team led by physicists at the University of California, Santa Cruz, used data from the Hubble Space Telescope to set a lower limit for the blazar's redshift (z ? 0.6035), which corresponds to a distance of at least 7.4 billion light-years. Over such a great distance, a substantial proportion of the gamma rays should be absorbed by the extragalactic background light, but calculations that account for the expected absorption yield an unexpected emission spectrum for the blazar.
"We're seeing an extraordinarily bright source which does not display the characteristic emission expected from a very high-energy blazar," said Amy Furniss, a graduate student at the Santa Cruz Institute for Particle Physics (SCIPP) at UCSC and first author of a paper describing the new findings. The paper has been accepted for publication in Astrophysical Journal Letters and is currently posted on arXiv.org.
Coauthor David Williams, adjunct professor of physics at UC Santa Cruz, said the findings may indicate something new about the emission mechanisms of blazars, the extragalactic background light, or the propagation of gamma-ray photons over long distances.
"We're finding very high-energy gamma-ray sources at greater distances than we thought we might, and in doing so we're finding some things we don't entirely understand," Williams said. "Having a source at this distance will allow us to better understand how much background absorption there is and test the cosmological models that predict the extragalactic background light."
The extragalactic background light (EBL) is the diffuse radiation from all stars and galaxies, a dim but pervasive glow that fills the universe. When a high-energy gamma-ray photon collides with a lower-energy EBL photon, they annihilate and create an electron-positron pair. The farther gamma rays have to travel the more likely they are to be absorbed by this mechanism. This limits the distance to which sources of very high-energy gamma rays can be detected.
Measuring the EBL is extremely difficult because there are so many bright sources of light in our immediate neighborhood. In addition to estimates based on cosmological models, astronomers have used galaxy counts to set a lower limit for the EBL. Using a model close to this lower limit to calculate the expected absorption of very high-energy gamma rays from PKS 1424+240, Furniss derived an intrinsic gamma-ray emission spectrum for the blazar. The results, however, deviate from the expected emission based on current blazar models.
Blazar emission is thought to result from a relativistic jet of particles powered by matter falling onto a supermassive black hole at the center of the host galaxy. "There may be something going on in the emission mechanisms of the blazar that we don't understand," Williams said. "There are more exotic explanations as well, but it may be premature to speculate at this point."
Gamma rays from PKS 1424+240 were first detected by the Fermi Gamma-ray Space Telescope and subsequently by the ground-based instrument VERITAS (Very Energetic Radiation Imaging Telescope Array System), which is sensitive to gamma-rays in the very high-energy (VHE) band from about 100 GeV to more than 10 TeV. To determine the redshift of the blazar--a measure of how much the light from an object has been stretched to longer wavelengths by the expansion of the universe--the researchers used data obtained by the Hubble Space Telescope's Cosmic Origins Spectrograph for another research program.
###
In addition to Furniss and Williams, the coauthors of the paper include J. Xavier Prochaska, professor of astronomy and astrophysics at UCSC; Joel Primack, professor of physics at UCSC; Michele Fumagalli, a former UCSC graduate student now at Carnegie Observatories and Princeton University; Charles Danforth and John Stocke at the University of Colorado; Meg Urry at Yale University; Alex Filippenko at UC Berkeley; and William Neely at the NF/ Observatory.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-04/uoc--dbi041813.php
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