Monday, December 31, 2012

Direct evidence for receptor's role in synapse development

Dec. 31, 2012 ? Jackson Laboratory researchers led by Associate Professor Zhong-wei Zhang, Ph.D., have provided direct evidence that a specific neurotransmitter receptor is vital to the process of pruning synapses in the brains of newborn mammals.

Faulty pruning at this early developmental stage is implicated in autism-spectrum disorders and schizophrenia. The definitive evidence for N-methyl-D-aspartate receptor (NMDAR) in pruning has eluded researchers until now, but in research published in the Proceedings of the National Academy of Sciences, Zhang's lab had serendipitous help in the form of a mouse model containing brain cells lacking NMDAR side-by-side with cells containing the receptor.

Soon after birth, mammals' brains undergo significant development and change. Initially, large numbers of synapses form between neurons. Then, in response to stimuli, the synaptic connections are refined -- some synapses are strengthened and others eliminated, or pruned.

In most synapses, glutamate serves as the neurotransmitter, and NMDAR, a major type of post-synaptic glutamate receptor, was previously known to play an important role in neural circuit development. Previous research has implicated the importance of NMDARs in pruning, but it remained unclear whether they played a direct or indirect role.

Zhang and colleagues focused on the thalamus, a brain region where synapse pruning and strengthening can be monitored and quantified with relative ease. They got unexpected help when they realized the mouse model they were using had thalamus cells lacking NMDARs right next to cells with normal NMDAR levels.

The researchers showed that the refinement process was disrupted in the absence of NMDARs. At the same time, neighboring neurons with the receptors proceeded through normal synaptic strengthening and pruning, clearly establishing the necessity of NMDARs in postsynaptic neurons for synaptic refinement.

"Whenever I give a talk or meet colleagues," Zhang says, "the first question that comes up is whether the NMDA receptor is important. It's good that this is now settled definitively."

There has been extensive research into synaptic strengthening, and most of these studies indicate that the presence of NMDARs may support the recruitment of larger numbers of another kind of glutamate receptor to strengthen the synaptic connections. How NMDARs regulate the pruning process remains largely unknown, however.

The Jackson Laboratory is an independent, nonprofit biomedical research institution based in Bar Harbor, Maine, with a facility in Sacramento, Calif., and a new genomic medicine institute in Farmington, Conn. It employs a total staff of more than 1,400. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

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Journal Reference:

  1. Zhong-Wei Zhang, Matthew Peterson, Hong Liu. Essential role of postsynaptic NMDA receptors in developmental refinement of excitatory synapses. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1212971110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/Ilph_sjEjzg/121231161049.htm

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Auburn postgame interviews - IlliniHQ Forums

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    #1 User is offline ? rob mccolley?

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    Thanks as always, Rob!

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    Thank you for posting these. Don't get to listen to the post game shows most of the time.

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    Rural DFLer isn't on edge over the cliff (Star Tribune)

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    Sunday, December 30, 2012

    Venus Williams leads US to victory over S. Africa

    AFP - American tennis star Venus Williams gave her comeback hopes a boost with a win at the Hopman Cup in Perth on Sunday, and said she still believed she could be a force in the Grand Slams.

    The former world number one beat Chanelle Scheepers in three sets to help the United States post a 2-1 win over South Africa in their Group B tie at the mixed teams tournament.

    Williams, playing for the first time since October and just 24 hours after arriving in Australia, made a slow start against the 60th-ranked Scheepers but steadied to win 4-6, 6-2, 6-3.

    The seven-time Grand Slam singles winner has climbed the rankings this year as she recovered from a major setback due to illness in 2011.

    Williams has not won a Grand Slam singles title since her 2008 success at Wimbledon. She slipped to 134th in the rankings last year after suffering from Sjogren's Syndrome, a systemic autoimmune disease.

    However, the 32-year-old has enjoyed much better fortunes this year.

    She won her first singles title since 2010 in Luxembourg, teamed with sister Serena to win gold in the doubles at the London Olympics and finished the season ranked 24th in the world.

    Speaking after hitting 44 winners in disposing of Scheepers, Williams said this year was a great platform for the coming 12 months.

    "Last year was so awesome for me, winning a tournament and getting to the Olympics and getting a gold," she said. "I was extremely happy last year and moved up quite a few spots.

    "This year is just about building on it and continuing to play deep into the draws and put myself in positions to play well deep into the tournaments."

    Williams said she still believed she could be a force in the Grand Slams.

    "I always feel that way," she said. "That's how you have to feel, you have to be positive.

    "I try to be positive and tell myself I'm the best now. It doesn't happen every time but you've got to have that mind frame."

    Kevin Anderson levelled the tie for South Africa with an upset win over fellow big man John Isner in the men's singles, the world number 37 beating the world number 14 after two tie-breaks, 7-6 (7/0), 7-6 (7/5).

    The Americans then prevailed in straight sets in the deciding mixed doubles 6-3, 6-2.

    In the evening Group A session Spain beat France 2-1, with Jo-Wilfried Tsonga recovering from a break down in the first set to beat Fernando Verdasco 7-5, 6-3 in the men's singles, before Anabel Medina Garrigues levelled the tie with an easy win over Mathilde Johansson, 6-3, 6-2.

    The Spanish dominated the mixed doubles, winning 6-3, 6-3.

    Meanwhile, Germany's Andrea Petkovic has withdrawn from the tournament after injuring her right knee during her singles match on Saturday, and will be replaced in the German team for the remainder of the tournament by Tatjana Malek.

    The injury-plagued Petkovic, a former top 10 player, has ruptured the meniscus in her right knee and will miss the Australian Open, but hopes to only be sidelined for a month.

    Source: http://www.france24.com/en/20121230-venus-williams-leads-us-victory-over-africa

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    Opposed to same-sex marriage, company ends wedding business

    An Annapolis, Md., company whose old-fashioned trolleys are iconic in the city's wedding scene has abandoned the nuptial industry rather than serve same-sex couples.

    The owner of Discover Annapolis Tours said he decided to walk away from $50,000 in annual revenue instead of compromising his Christian convictions when same-sex marriages become legal in Maryland in less than a week. And he has urged prospective clients to lobby state lawmakers for a religious exemption for wedding vendors.

    While many wedding businesses across the country have embraced the chance to serve same-sex couples, others have struggled to balance religious beliefs against business interests.

    Wedding vendors elsewhere who refused to accommodate same-sex couples have faced discrimination lawsuits ? and lost. Legal experts said Discover Annapolis Tours sidesteps legal trouble by avoiding all weddings.

    ?If they're providing services to the public, they can't discriminate who they provide their services to,? said Glendora Hughes, general counsel for the Maryland Commission on Civil Rights. The commission enforces public accommodation laws that prohibit businesses from discriminating on the basis of race, sexual orientation and other characteristics.

    The trolley company's decision offers a snapshot of a local business navigating a new landscape in the wedding industry, and leaving it behind for a competitor to swoop in.

    The head of the Maryland Wedding Professionals Association said the trolley company is the second vendor to refuse business over the state's same-sex marriage law, which voters upheld in November. The Maryland clergyman who led opposition to same-sex marriage called the trolley company's choice to abandon profits on principle ?gutsy? and predicted that more businesses would follow suit.

    ?That's a bold and noble statement,? said Derek McCoy, executive director of the Maryland Marriage Alliance. ?The other option would have been just to become a legal case.?

    Frank Schubert, a political strategist who ran campaigns against same-sex marriage in Maryland and three other states this year, said opponents predicted collateral damage.

    ?This is exactly what happens,? Schubert said, adding that religious liberty is ?right in the cross hairs of this debate. The law doesn't protect people of faith. It simply doesn't.?

    Schubert pointed to a handful of other examples publicized in news reports across the country of wedding vendors sued for refusing to accommodate a same-sex ceremony: a pair of Vermont innkeepers, a New Jersey church group and a New Mexico wedding photographer.

    In Maryland, the gay-rights group Equality Maryland said the trolley company's decision appears to be an isolated case of a business owner exercising his rights.

    ?As long as he doesn't discriminate against other people, he's free to do whatever he wants to do, including withdrawing his business from the industry,? executive director Carrie Evans said.

    Discover Annapolis Tours owner Matt Grubbs declined repeated requests to discuss the move, beyond acknowledging its economic impact to his business, which also operates historic tours.

    Source: http://www.omaha.com/article/20121230/MONEY/712309924

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    President of Azerbaijan approves amendments to Tax Code

  • News.Az - Sunday 30th December, 2012

    Preparations for withdrawal of Russian equipment from Gabala radar are underway in Azerbaijan. The statement came from Foreign Minister Elmar Mammadyarov. "As is known, the Azerbaijani ...

  • ASAN service launched in Azerbaijan

    News.Az - Sunday 30th December, 2012

    A new service for the population of Azerbaijan ASAN xidmet is to start functioning from January. The statement came from chairman of the State Agency for Services to Citizens and Social ...

  • Azerbaijan stands for peaceful solution of Karabakh conflict ? minister

    News.Az - Sunday 30th December, 2012

    Azerbaijan is ready to direct its high economic potential for the development of the region, Azerbaijani Foreign Minister Elmar Mammadyarov has said in an interview with a number of media. ...

  • 2012 marked for Azerbaijans success in Euro-Atlantic integration - MP

    News.Az - Sunday 30th December, 2012

    In the outgoing 2012 Azerbaijan successfully continued its strategy of Euro-Atlantic integration, MP Asim Mollazade believes. "In this respect, the most memorable event in the parliamentary ...

  • Central Asian migrants change the face of Moscow - Quincy Herald-Whig | Illinois Missouri News Sports

    General Sources - Sunday 30th December, 2012

    By MANSUR MIROVALEVAssociated Press MOSCOW (AP) - Timur Bulgakov has a black belt in karate, two university degrees, a powerful SUV and a small yet thriving construction company. The ...

  • Purchase contract and Transmission Agreement signed for Uzbek gas

    Neftegaz - Sunday 30th December, 2012

    As part of the visit, Alexander Medvedev and Shokir Faizullaev, Chairman of the Board of Uzbekneftegaz signed in the presence of Rustam Azimov, First Deputy Prime Minister of Uzbekistan a contract ...

  • Mongolia takes a chance to move on

    Asia Times - Sunday 30th December, 2012

    , by Jeffrey Reeves (See Asia Times Online, December 8, 2012). On December 6, Mongolia's cabinet ministers attended a meeting with the members of the National Security Council where they ...

  • German company seeks partner in Azerbaijan

    News.Az - Sunday 30th December, 2012

    German meet trade company KG MTI-Vertriebsgesellschaft mbH & Co is looking for a partner and importer in Azerbaijan, AZPROMO has told Gun.Az. The company has a long experience in supplying ...

  • YAP considers 2012 successful for Azerbaijan

    News.Az - Sunday 30th December, 2012

    The farewell year of 2012 was successful for Azerbaijan, New Azerbaijan Party's (YAP) executive secretary, Ali Ahmadov, has said. According to the YAP deputy chairman, this year entered our ...

  • Georgia to receive additional 600 MW from Azerbaijan

    News.Az - Sunday 30th December, 2012

    Georgia will receive additional 600 MW from Azerbaijan within the first three months of the new year. The Georgian authorities have agreed to supply 200 MW per month in the first quarter of the ...

  • Turkey and Azerbaijan hold strategic position in Europes energy security

    News.Az - Sunday 30th December, 2012

    Turkish PM comments on TANAP project. Having decided on the TANAP pipeline project, Turkey and Azerbaijan have taken a strategic position in Europe's energy security, Prime Minister Recep ...

  • Russias Korea projects gather dust

    Asia Times - Saturday 29th December, 2012

    By Stephen Blank In August 2011, Russia signed what appeared to be a momentous agreement with North Korea (Democratic People's Republic of Korea - DPRK), an accord that marked Kim ...

  • Source: http://www.turkmenistannews.net/index.php/sid/211667181/scat/929bcf2071e81801

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    Saturday, December 29, 2012

    'Do something!' Americans fed up with D.C. over 'cliff'

    Americans from across the country express their frustration with lawmakers in Washington who have yet to reach an agreement on averting looming tax increases.

    By Tracy Connor, NBC News

    Tennessee Sen. Bob Corker said Friday that ?the American people should be disgusted? the nation?s leaders haven?t been able to avert the fiscal cliff.

    Well, mission accomplished.

    John Makely / NBC News

    Abigail Holt, 17, (right), of Hartford, Conn., says Washington's inability to avert the fiscal cliff is "annoying."

    Across the country, people are shaking their heads about negotiations that go nowhere and fingers that point everywhere while the nation hurtles toward the precipice of a new economic crisis.

    ?They should make a plan, make up their minds and do something!? Abigail Holt of Hartford, Conn., told NBC News.

    She?s 17 years old and admits she?s just learning about the federal government and the fiscal cliff. But she knows this much: ?It?s annoying.?

    And that's being polite.

    Writing in the Daily Beast, Howard Kurtz called the nation's capital "the country?s biggest day-care center." The famous sex therapist Dr. Ruth Westheimer hit below the belt, noting on Twitter that "Members of Congress who can't compromise probably aren't good lovers."

    Californian Pat Marshall said the politicians "appear to be very self-centered on making sure that they?re taken care of and the American public comes second."

    After an hourlong meeting Friday with congressional leaders that he described as "constructive," President Obama acknowledged that people outside Washington were bewildered by D.C. "dysfunction" and that time -- and patience -- were running out.

    Lawmakers have 'lost touch'
    Indeed, with higher taxes and deep spending cuts looming without a deal, Americans? faith in Washington is dissipating by the day.

    A Dec. 9 Gallup poll found that 59 percent thought it was likely the White House and Congress could hammer out a deal to avoid a slide down the cliff; by this week, that had sunk to 50 percent.

    Skeptics were gaining ground, meanwhile: 48 percent think an agreement before the year-end deadline is unlikely, up 10 points from two weeks earlier.

    John Makely / NBC News

    Rich Dodds, 49, of Houston, Texas, says the elected officials in Washington have "lost touch" with Americans who will be affected by the fiscal cliff.

    ?It doesn?t feel like they?re doing much,? said Rich Dodds, 49, an energy product manager from Houston, Texas. ?I think they?ve lost touch with who the American people are. It?s a pretty elite group in Washington.?

    The fact that both houses of Congress went into recess -- the Senate took a nearly week-long break, and the House is still on vacation until Sunday -- bothered some.

    ?This is one of the most important issues and they are not even working,? said Bill Prosser, 49, a telecommunications salesman from Clifton, Va. ?I?m very disappointed in them.?

    Nicole Hayward, 28, of Brooklyn, N.Y., was so angered by the congressional recess that she posted a petition on Change.org demanding lawmakers get back to business.

    ?I turn on the news every day while I?m getting ready for work and I saw coverage about how Congress was going to break for the holidays and we might not have a resolution,? the marketing director said. ?I thought, who cares about their holiday vacation? It really got me going.?

    Hayward got only 101 signatures on her petition. She attributed the lack of interest to cynicism.

    ?The reason why the average American doesn?t pay attention to this issue and the details is they think Congress will come together and pass something that just kicks the can down the road and things won?t change in [their] life,? she said.

    John Makely / NBC News

    Bill Prosser, 49, of Clifton, Va., says members of Congress should be locked in a room until they can make a deal.

    Bipartisan blame
    Inside the Beltway, Democrats are condemning Republicans and vice versa for the stalemate. But the nation?s voters are more bipartisan in their blame, with neither Republicans nor Democrats obtaining majority support.

    ?Essentially, right now, 25 percent of the public approves of the job the GOP congressional leaders are doing and 40 percent approves of the job the Democratic leaders are doing,? said Jocelyn Kiley, a senior researcher for the Pew Research Center for the People & the Press.

    Prosser thinks there?s a time-tested way to bring the two sides together before Jan. 1 -- something akin to the old papal conclaves in which cardinals were locked in a room until they chose a new pontiff.

    ?Just say you?re not going to leave until you have a deal,? Prosser said.? ?Get in a room -- and get it done!?

    Who do you blame for the nation teetering on the edge of the fiscal cliff?

    ?

    Source: http://usnews.nbcnews.com/_news/2012/12/29/16216300-do-something-americans-fed-up-with-washington-as-fiscal-cliff-deadline-looms?lite

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    No light, no light (Unqualified Offerings)

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    Friday, December 28, 2012

    NASA'S Space Launch System core stage passes major milestone, ready to start construction

    Dec. 28, 2012 ? The team designing America's new flagship rocket has completed successfully a major technical review of the vehicle's core stage. NASA's Space Launch System (SLS) will take the agency's Orion spacecraft and other payloads beyond low-Earth orbit, providing a new capability for human exploration.

    The core stage preliminary design review (PDR) was held Thursday (Dec. 20) at NASA's Marshall Space Flight Center in Huntsville, Ala., and included representatives from the agency and The Boeing Co. Boeing's Exploration Launch Systems in Huntsville is the prime contractor for the core stage and its avionics. Marshall manages the SLS Program.

    "Passing a preliminary design review within 12 months of bringing Boeing on contract shows we are on track toward meeting a 2017 launch date," said Tony Lavoie, manager of the SLS Stages Element at Marshall. "We can now allow those time-critical areas of design to move forward with initial fabrication and proceed toward the final design phase -- culminating in a critical design review in 2014 -- with confidence."

    The first flight test of the SLS, which will feature a configuration for a 70-metric ton lift capacity and carry an uncrewed Orion spacecraft beyond the moon, is scheduled for 2017. As the SLS evolves, a two-stage launch vehicle using the core stage will provide a lift capability of 130-metric tons to enable missions beyond low-Earth orbit and to support deep space exploration.

    The purpose of the PDR was to ensure the design met system requirements within acceptable risk and fell within schedule and budget constraints. An important part of the PDR was to prove the core stage could integrate safely with other elements of the rocket's main engines and solid rocket boosters, the crew capsule and the launch facilities at NASA's Kennedy Space Center in Florida. Core stage designers provided an in-depth assessment to a board of engineers composed of propulsion and design experts from across the agency and the aerospace industry.

    "Each individual element of this program has to be at the same level of maturity before we can move the program as a whole to the next step," SLS Program Manager Todd May said. "The core stage is the rocket's central propulsion element and will be an optimized blend of new and existing hardware design. We're building it with longer tanks, longer feed lines and advanced manufacturing processes. We are running ahead of schedule and will leverage that schedule margin to ensure a safe and affordable rocket for our first flight in 2017."

    The core stage will be built at NASA's Michoud Assembly Facility in New Orleans using state-of-the-art manufacturing equipment. The plant continues modifying its facilities and ordering materials for construction of the rocket. Michoud has built components for NASA's spacecraft for decades, most recently, the space shuttle's external tanks.

    For more information about the Space Launch System, visit: http://www.nasa.gov/sls

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    The above story is reprinted from materials provided by NASA.

    Note: Materials may be edited for content and length. For further information, please contact the source cited above.


    Note: If no author is given, the source is cited instead.

    Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/space_time/astronomy/~3/FlBBMtAU4Oo/121228100748.htm

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    Nervous retailers hope for post-Christmas rush

    19 hrs.

    The biggest holiday of the season is over, but retailers are hoping that you aren?t done with your holiday shopping quite yet.

    ?The next few days are critical for retailers. They?ve got some catching up to do,? said Marshal Cohen, retail industry analyst with NPD Group.

    On Wednesday, big chains including Macy's were already pushing their post-Christmas bargains, while major discounters?including Wal-Mart were encouraging shoppers to redeem their gift cards right away. But the fallout from a big Christmas storm could hurt their efforts if shoppers decide they prefer a cozy rest of the week at home instead.

    Retailers had started off the all-important holiday shopping season in a much cheerier mood, as Black Friday shoppers appeared to gobble down turkey and rush to the stores ? and their computers ? in search of holiday gifts and bargains.

    But then, a combination of factors including Superstorm?Sandy and the political upheaval over the fiscal cliff appeared to dim shoppers? moods. Experts also?said the stronger start to the season may have been a sign that people finished up early and had fewer last-minute shopping trips to make.

    ?The early start certainly looked like it meant that the consumer was in full spirits,? Cohen said. ?But in reality just because they had a front-loaded holiday didn?t mean there was going to be that much more spending to come.?

    It's too early to paint a complete picture of how retailers fared so far in the most crucial season of the year. But early indications have some fretting that the year will end up being weaker than many had initially hoped.

    Holiday-related sales rose 0.7 percent from Oct. 28 through Dec. 24, as compared to last year, according to data from Mastercard Advisors SpendingPulse. That was the lowest growth rate for that period?since 2008, at the depths of the recession. The same?survey showed a 2 percent increase in 2011.

    The SpendingPulse data is based on estimates of payments made through the MasterCard network as well as by cash and check. It tracks holiday-related purchases including apparel, electronics and jewelry.

    Research firm ShopperTrak, which compiles sales estimates based on foot traffic, said last week that it expects holiday sales to increase by 2.5 percent. That?s down from?its previous estimate that sales would increase by 3.3 percent.

    But other researchers have not changed their initial forecasts for the season.

    On Wednesday, the International Council of Shopping Centers, which produces an index of chain store sales along with Goldman Sachs, said it was holding to its estimate that holiday sales at chain stores would rise 3 percent this year.

    ?The ICSC?s chief economist, Michael Niemira, said in a note that sales in the last week of December could benefit from a calendar shift that put Christmas Eve on Monday this year.

    A National Retail Federation spokeswoman said in an e-mail Wednesday that it also was sticking with its forecast that holiday sales would grow 4.1 percent to $586.1 billion.

    Experts caution that it?s hard to say just yet what the final data will show, especially once post-holiday bargains are factored in.

    ?There?s no question that we saw a lot of (the) momentum slow down. How much did it slow down? We don?t really know yet,? Cohen said.

    Holiday sales are considered crucial to retailers, and some can expect to make as much as half their profits, and 30 percent of their sales, during the two-month period.

    The fiscal cliff, Superstorm?Sandy and other external factors are partly to blame for souring shoppers? moods toward the end of the season. But experts say shoppers have in recent years also become more savvy about sussing out bargains.

    They?ve also become more bargain-conscious. C. Britt Beemer, retail analyst with America?s Research Group, said in a research note that major discounters appeared to fare best in keeping their customers.

    ?Consumers were very frugal this year, as we said all along,? Beemer said in the note.

    The increasing shift to online shopping also may not be helping retailers pick up any extra sales. That?s because when a person shops online, they tend to seek out the best bargain and then buy that item. An in-store shopper may be more tempted to walk the other aisles, pick up a few things for themselves or do some other impulse shopping they hadn?t planned on.

    ?The consumer didn?t spend a lot of time this year buying those extra gifts. They didn?t spend a lot of time spending on themselves instead of others,? Cohen said.

    Information from Reuters was included in this report.

    Source: http://www.nbcnews.com/business/economywatch/nervous-retailers-hope-post-christmas-rush-1C7659314

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    Private company to offer rides to moon by 2020

    Golden Spike says it hopes to sell missions to the moon for over $1 billion.

    By Clara Moskowitz,?SPACE.com / December 7, 2012

    This undated image made available by NASA and photographed by the Expedition 28 crew aboard the International Space Station, shows the moon, at center with the limb of Earth near the bottom transitioning into the orange-colored troposphere, the lowest and most dense portion of the Earth's atmosphere.

    NASA/AP

    Enlarge

    A new private venture aims to sell manned trips to the moon by 2020, its founders announced today (Dec. 6).

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    The company, called Golden Spike (after the final spike built into the First Transcontinental Railroad), plans to sell each moon mission for about $1.5 billion ? a relative bargain, said the company's president and CEO Alan Stern, a former director of NASA?s Science Mission Directorate.

    For the same price as many unmanned robotic missions, Golden Spike will provide a round trip for two humans to the moon.

    "We're selling to nations, corporations and individuals," Stern told SPACE.com. "Get in line ? and I think it's going to be a long one." [How Golden Spike's Moon Landing Plan Works (Infographic )]

    Stern and Golden Spike's chairman of the board of directors, Gerry Griffin, a former Apollo flight director and NASA Johnson Space Center director, announced their plans today at the National Press Club in Washington, D.C.

    Shopping for a rocket

    The company's leaders have not yet chosen a launch vehicle or space capsule to transport their passengers; Stern expects to make the final selections in 2014.

    To keep costs low, Golden Spike will likely use existing or already-under-development rockets and spacecraft. However, the company will need to commission its own lunar lander and specially designed spacesuits. Stern called rumors that Golden Spike had already chosen SpaceX's Falcon 9 Heavy rocket "not true."

    The company has been in the works, and under wraps, for two and a half years, Stern said.

    "I don?t think anybody's got us beat," he added. "This is state-of-the-art cool."

    The missions are being targeted at countries without their own space agencies or that can't afford to launch people to the moon independently, as well as scientific organizations and even private individuals looking to take the trip of a lifetime.

    "We have spoken to space agencies from both Asian and European countries and found real interest," Stern said.

    Private moon race

    Source: http://rss.csmonitor.com/~r/feeds/science/~3/UbH0hPTO37Q/Private-company-to-offer-rides-to-moon-by-2020

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    Thursday, December 27, 2012

    business marketing | Mombasa.travel

    Where do you want to go?

    Source: http://www.mombasa.travel/business-marketing-2/

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    An Unpublished Writer's Wall of Fame ? Marmaduke Writing Factory

    When I was a teenager, back in the 1970s, I had a big poster of the Marx Brothers above my bed (the brothers? eyes would follow you around the room, which was creepy enough that late one night I tore the poster down); quotes from favorite movies (Casablanca, M, The Maltese Falcon, more Marx Brothers) around my bookshelf; and curling old 8x10s of the New York Mets near the door.

    Oh, and a wall full of rejection slips over my desk.

    I was about eight when I decided I wanted to be a writer, and maybe fourteen when I took that desire public, so to speak, by submitting my work to magazines, newspapers, and even more far-flung destinations. My benchmark, my guide, my Bible: Writer?s Market, a huge tome that listed every possible outlet for my prose. There came a time when I knew the name of the articles editors of everything from The New Yorker to the Old Farmer?s Almanac.

    As the results dribbled in?self-addressed stamped envelopes dropping through our mail slot?out would come the Scotch tape and up would go the rejection slip. A form letter, every time, always using roughly the same words: We are sorry to inform you?. Does not suit our present needs?. Best of luck in the future?.?One magazine, possibly?The Atlantic,?said, Please excuse this impersonal form of reply, which I thought sounded especially?personal.

    Why was I so proud of my rejection slips? Why I would show them off, instead of burying them in a drawer or tossing them into the trash? Maybe it was because the letters themselves,?with their famous titles at the top, made me feel like I was a real writer. (Someone in those hallowed editorial offices had read my writing, or at least a few sentences of it!)?Or maybe I was just hardening myself to the realities of the writing life, getting ready for a career necessarily filled more with disappointment than glory.

    I don?t know.

    I never received the rejection slip reproduced above. (It was sent by a film company to a prospective screenwriter in 1920, and I found it online.) But here?s one thing I do know: If I had, I wouldn?t have been crushed. The letter would immediately have gotten pride of place on my Wall of Fame.

    And then, unbowed, I would have sat down at my clattery Olympia typewriter and tried again.

    Source: http://www.marmadukewritingfactory.com/2012/12/26/the-unpublished-writers-wall-of-fame/

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    jazz: antonycarrickxx: victorrusso23: Shopping And Product Reviews

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    Wednesday, December 26, 2012

    agakhan: Renting Cabins In GeorgiaTravel & Leisure | Travel ...

    The peach state, Georgia offers a lot of relaxing southern atmosphere. Some people prefer to take in this beautiful state by renting cabins instead of hotel rooms. Renting Cabins In GeorgiaGeorgia is a great vacation spot for friends and family. Whether you would rather stay in north Georgia, home of the Blue Ridge Mountains, or closer to Florida, Georgia is the way to go. Cabins are an economical and fun way to stay together as a family without the hustle and expense of a hotel. While being more like a home away from home, they offer the amenities of a house with the rustic charm of camping ? all with Southern hospitality.If you think you might enjoy the hiking, fishing and natural wonders of the Blue Ridge mountains, north Georgia is definitely for you. This area is home to mountain peaks of over 4000 feet, and even a spot where you can see three states! The town of Blue Ridge, Georgia, is a great place to set up your home base, and with tons of different cabin options to choose from, you will be sure to find one that suits your needs.Premier Cabin Rentals, based out of Blue Ridge, offers many different styles of cabin for rent. All cabins include a hot tub and at least one fireplace for that relaxing country feel. Cabins are available on Lake Blue Ridge (these range from three to five bedrooms), as well as in the mountains themselves. Amenities vary by cabin, and some have game rooms, arcades and other additions to their standard list of items. Standard amenities include a kitchen stocked with utensils, pots and pans and other necessities, linens and towels, as well as entertainment: a TV with satellite and a DVD player or VCR.The Last Resort, also located in Blue Ridge, offers both rustic and deluxe cabins with one to four bedrooms each. These cabins are all situated in the beauty of the Blue Ridge Mountains, and they all include hot tubs, satellite TV, and fully furnished kitchens. Air conditioners are present in the bedrooms, and all linens and other needs are provided (bring your own toiletries).The deluxe cabins also have central air.Choosing to stay in one of the many Georgia cabin options available can make a family trip even more memorable. Whether you would rather get away from it all with a rustic touch, or enjoy the feel of home on your trip, Georgia cabins are the way to do it all in style. Many of the cabins are not just family friendly, but pet friendly (be sure to ask your resort), so the entire family, furry included, can be in on the fun!

    This entry was posted in Travel Tips by . Bookmark the permalink.

    Source: http://searchdamage.com/renting-cabins-in-georgia.html

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    Source: http://agakhan47.blogspot.com/2012/12/renting-cabins-in-georgiatravel-leisure.html

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    Set Up and Get to Know Your New iPhone, iPad, or iPod touch

    Set Up and Get to Know Your New iPhone, iPad, or iPod touchYou've just been given an iDevice: a magical entity that bestows the gift of more apps than you can fathom. We'll help you make sense of it all with some great apps, tips, and tricks for your shiny new Apple toy.

    Before you dive in, here are a few things you should do with your new iDevice first:

    • Update to the Lastest Version of iOS: There's a decent chance your new iDevice isn't running the latest version of iOS, even if it's just a very minor upgrade that's necessary. Before you sync for the first time, check for updates in iTunes or in your iDevice's Settings app, if your device is running iOS 6.0.1. If there's an update available, iTunes (or your phone) should tell you automatically but it's always good to double check. It's okay to update now that Google Maps is available.
    • Get to Know iOS 6: Once you've updated, you ought to know what you're in for. We can teach you everything you need to know. Our guide features a rundown of new features, in-depth looks at how to use the most popular ones, and answers to common questions about the mobile operating system.
    • Sign Up For Free Find My iPhone: You don't need to pay to use Apple's great Find My iPhone app. Just download it from the iTunes App Store and follow the signup instructions. You'll need to create a MobileMe account to get it to work but you will not have to pay for it. Once you're all set up, you'll be able to find your lost or stolen iPhone much more easily.
    • Install Google Maps - When Apple released iOS 6, everyone complained about the problems with their new Maps app?and for good reason. Fortunately, Google came to the rescue and released Google Maps with turn-by-turn navigation. Do yourself a favor and install it, then learn how to integrate it with Siri.
    • Organize Your Home Screen - When you start downloading a bunch of apps, your home screen is going to get cluttered very quickly. Stay ahead of the game and start organizing. As you download apps it'll be easier to keep track of where every app is and will be stored. Check out these reader tips for some ideas.

    Download Some Killer Apps

    One of the iPhones primary draws is the high quality of apps in the iTunes App Store. Here are some app suggestions to get you started.

    Set Up and Get to Know Your New iPhone, iPad, or iPod touch

    • Lifehacker Pack for iPhone: Our List of the Best iPhone Apps: Looking to power up your iPhone with the best free and cheap apps out there? Our second edition of the Lifehacker Pack for iPhone rounds up our favorite must-have iPhone applications.
    • The iPhone App Directory: Our App Directory is a new and growing directory of the best applications and tools for various platforms, and in this case the iPhone. If you're looking for the best app in any category, this is where you want to look. Visit the iPhone App Directory
    • The Best "Evil" Apps for iPhone: Locked down for your "safety," your iPhone is designed to operate the way Apple intended. With recently relaxed app store policies and great strides within the jailbreaking community, however, you can add great functionality that Apple never wanted you to have.

    Supercharge Your iPhone

    There's a wide world of fun beyond apps. Check out these posts to learn all about the awesome things you can do to supercharge your iPhone's capabilities.

    Set Up and Get to Know Your New iPhone, iPad, or iPod touch

    • How to Break Down the Barrier Between Your iPhone and Computer: Your iOS device is a killer pocketable computer; your desktop is more powerful with a bigger screen. They need to play better together. Here's how to break down the barrier between the two and shuttle text, files, media, and more seamlessly between your desktop and iPhone.
    • How to Create a Visual Speed Dial Folder on Your iPhone: Visual speed dial is a nice idea, but when you have to launch a separate app to make a phone call it's a little annoying. Here are two ways to add visual speed dial to your home screen.
    • Top 10 Handy iOS Tweaks That Don't Require Jailbreaking: Jailbreaking your iPhone has a ton of benefits that give you actual control over your device-but it isn't always possible. If you're tired of waiting for the next version of iOS to be jailbroken, check out these tweaks and customizations you can make whether you're jailbroken or not.
    • Turn Your Smartphone Camera into a Pocketable Photographic Memory: Several apps exist to help you remember the many things you'd otherwise forget, but perhaps none are quite as useful and efficient as your camera. Typing takes time. napping a photo only takes a moment, and there are so many ways you can remind yourself better with nothing but a picture.
    • How to Turn Your Phone Into a Mind-Reading Personal Assistant: Smartphones, despite their name, are actually pretty dumb. They only do what you tell them to, and constantly inputting information can get tedious. However, with a few apps, you can not only make your phone smarter, but turn it into a mind-reading personal assistant that lets you know of important information as you need it: like traffic for your commute, a reminder to pick up milk as you pass the grocery store, and even automatic text messages to your friends when you're driving to meet them. Here's how to do it.
    • Make Your Smartphone's Ringtones and Alerts Actually Useful and Informative?: Don't settle for the same ringtone for every contact and every app. Make your tones actually useful so you know what kind of notification you're getting without the need to look at the screen.
    • Do Yourself a Favor: Set Up These Custom Typing Shortcuts on Your iPhone Right Now: It seems Apple added text expansion to iOS 5 and decided not to mention it. This is a great, highly-desired feature that can save you tons of time typing frequent phrases and long words. Here's how to set it up and some phrases you'll want to add right away.
    • How to Take Great Holiday Photos with Your iPhone: Holidays are the perfect time to capture magic moments with friends and family and take the time get creative with your photography. Here are some simple tips to get the best photos from your iPhone.
    • Use Your iPad or Android Tablet as a Second Monitor for Your Computer: Want to eke out a little more value out of that tablet? Turn it into a second monitor for your PC or Mac and extend your screen real estate.
    • How to Migrate All Your Data to iCloud from Google with Minimal Fuss: While most of us use Gmail for all our cloud computing needs, Apple's iCloud actually has some really nice things going for it-especially if you're a heavy Mac and iOS user. I've walked through why you might want to switch from Google's apps to iCloud, so whether you're migrating all your data over or just a few choice items, here's how to move from Google to iCloud without losing any of your existing email messages, contacts, calendars, and documents.
    • How to Turn Your iPod touch into an iPhone: 4G Edition: The latest iPhone and iPod touch are nearly identical devices on the inside, ignoring the pesky reality that the latter isn't a phone. We can fix that. Here's how to turn your iPod touch into a viable (and cheaper) iPhone alternative out of the box.
    • How to Google-ify Your iPhone: Got Android envy? Just wish Apple handled sync, the web, and openness a bit better? You can't have it all, but if you want to bring more Google paradigms to your iPhone, here's how to do it.
    • How to Make Music in GarageBand with iOS: Want to lay down some tracks but all you've got is your iOS device and a Mac? With an OpenSound Control (OSC) app on your iPhone and server on your Mac you can record a virtual keyboard over Wi-Fi.

    Fix Common Problems

    Set Up and Get to Know Your New iPhone, iPad, or iPod touch

    • How to Stop Your Smartphone from Secretly Wasting Data in the Background: Unlimited data plans are an endangered species nowadays, so most of us have to watch our limits in order to avoid excess charges on our bill. That's easy enough when we know how much cellular data we're using on our smartphones, but becomes problematic when our smartphones eat up our precious megabytes in the background. This doesn't just happen on Android, but iPhone, too. Here's how to stop it.
    • How to Improve Your iPhone's Battery Life: If you're looking to improve your iPhone's daily lifespan, we've got a few tips that can help you squeeze a little more juice out of your iDevice.
    • Fill Out Your Address Book to Make Siri Work Better: Out of the box Siri can do a few common things, but it struggles when you try to get too complicated with it. GigaOM offers up a few clever address book customizations to make Siri work more naturally.
    • How to Copy Music from Your iPhone, iPad, or iPod touch to Your Computer for Free: Apple, true to form, makes it simple to put media and files on your iDevice but the road really only goes one way. It can be pretty difficult to copy anything (or everything) back to your computer without a lot of trouble and sacrifice, but it's even harder to find a good, free solution to that problem amongst the many choices available. You could spend the better part of your holiday sifting through your options, or you could just read this guide instead.
    • How to Sync Documents and Other Files to Your iPhone or iPad Without iTunes: If you use a word processor, comic book or PDF reader, video player, or other app that requires syncing files through iTunes, you know how slow and awful it can be. Here's a simple, fast alternative.
    • How to Encode Video for All Your Mobile Devices: With H.264 solidly planted as the codec of choice for just about every mobile device, we've come to a point where you can encode a video once and play it back on pretty much anything.
    • Printopia Enables iOS-to-Mac AirPrint Support Hack-Free, Adds Virtual Printers: You could use AirPrint Hacktivator (or do it manually) to add AirPrint support to your Mac, but if you don't want to modify your system files and would like virtual printers, you should check out Printopia.
    • How to Open Compressed Files on Your iOS Device: iOS does pretty well with handling various file types, but when it comes to compressed files you run into problems. Fortunately, with the aid of a file browsing app you'll be able to view compressed files easily.

    Images by ecco (Shutterstock), kirillov alexey (Shutterstock), and PixelBin.

    Source: http://feeds.gawker.com/~r/lifehacker/full/~3/QVSoTk18wqI/set-up-and-get-to-know-your-new-iphone-ipad-or-ipod-touch

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    Obama to cut short holiday in Hawaii, leave Wednesday for Washington as 'fiscal cliff' looms (Star Tribune)

    Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

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    Tuesday, December 25, 2012

    Thousands enjoy merry Christmas in Bethlehem

    Latin Patriarch of Jerusalem Fouad Twal waves to the crowds before Christmas celebrations in the West Bank town of Bethlehem, Monday, Dec. 24, 2012. Twal, the top Roman Catholic cleric in the Holy Land, has celebrated the United Nations' recent recognition of a Palestinian state in his annual pre-Christmas remarks.(AP Photo/Adel Hana)

    Latin Patriarch of Jerusalem Fouad Twal waves to the crowds before Christmas celebrations in the West Bank town of Bethlehem, Monday, Dec. 24, 2012. Twal, the top Roman Catholic cleric in the Holy Land, has celebrated the United Nations' recent recognition of a Palestinian state in his annual pre-Christmas remarks.(AP Photo/Adel Hana)

    People walk inside the Church of Nativity, traditionally believed by Christians to be the birthplace of Jesus Christ, ahead of Christmas, in the West Bank town of Bethlehem, Sunday, Dec. 23, 2012. (AP Photo/Nasser Shiyoukhi)

    A man dressed as Santa Claus distributes Christmas trees to Christians outside Jaffa Gate in the Old City of Jerusalem, Sunday, Dec. 23, 2012. (AP Photo/Mahmoud Ilean)

    Catholic priests attend Christmas celebrations in the West Bank town of Bethlehem, Monday, Dec. 24, 2012. (AP Photo/Nasser Shiyoukhi)

    A Christian worshipper prays inside the Grotto at the Church of Nativity, traditionally believed by Christians to be the birthplace of Jesus Christ, in the West Bank town of Bethlehem, Monday, Dec. 24, 2012. Thousands of Christian worshippers and tourists arrived in Bethlehem on Monday to mark Christmas at the site many believe Jesus Christ was born. (AP Photo/Adel Hana)

    (AP) ? Thousands of Christians from the world over packed Manger Square in Bethlehem Monday to celebrate the birth of Jesus in the ancient West Bank town where he was born.

    For their Palestinian hosts, this holiday season was an especially joyous one, with the hardships of the Israeli occupation that so often clouded previous Christmas Eve celebrations eased by the United Nations' recent recognition of an independent state of Palestine.

    Festivities led up to the Midnight Mass at St. Catherine's Church, next to the fourth-century Church of the Nativity, built over the grotto where tradition says Jesus was born.

    "From this holy place, I invite politicians and men of good will to work with determination for peace and reconciliation that encompasses Palestine and Israel in the midst of all the suffering in the Middle East," said the top Roman Catholic cleric in the Holy Land, Latin Patriarch Fouad Twal in his annual address. "Please continue to fight for a just cause to achieve peace and security for the people of the Holy Land."

    In his pre-Christmas homily, Twal said the road to actual freedom was still long, but this year's festivities were doubly joyful, celebrating "the birth of Christ our Lord and the birth of the state of Palestine."

    "The path (to statehood) remains long, and will require a united effort," added Twal, a Palestinian citizen of Jordan, at the patriarchate's headquarters in Jerusalem's Old City.

    Then he set off in a procession for the West Bank city of Bethlehem, Jesus' traditional birthplace. There, he was reminded that life on the ground for Palestinians has not changed since the U.N. recognized their state last month in the Israeli-occupied West Bank and east Jerusalem and the Hamas-ruled Gaza Strip.

    Twal had to enter the biblical town through a massive metal gate in the barrier of towering concrete slabs Israel built between Jerusalem and Bethlehem during a wave of Palestinian suicide bombings in the last decade. The Israeli military, which controls the crossing, said it significantly eased restrictions for the Christmas season.

    Israel, backed by the United States, opposed the statehood bid, saying it was a Palestinian ploy to bypass negotiations. Talks stalled four years ago.

    Hundreds of people greeted Twal in Manger Square, outside the Church of Nativity. The mood was festive under sunny skies, with children dressed in holiday finery or in Santa costumes, and marching bands playing in the streets.

    After nightfall, a packed Manger Square, resplendent with strings of lights, decorations and a 17-meter (55-foot) Christmas tree, took on a festival atmosphere, as pilgrims mixed with locals.

    A choral group from the Baptist Church in Jerusalem performed carols on one side of the square, handing out sheets of lyrics and encouraging others to sing along with songs such as "We Wish You A Merry Christmas."

    Vendors sold balloons, cotton candy and corn on the cob, bands played Christmas songs and tourists packed cafes that are quiet most of the rest of the year. Pilgrims from around the world wandered the streets, singing Christmas carols and visiting churches.

    Devout Christians said it was a moving experience to be so close to the origins of their faith.

    "It's a special feeling to be here, it's an encounter with my soul and God," said Joanne Kurczewska, a professor at Warsaw University in Poland, who was visiting Bethlehem for a second time at Christmas.

    Pastor Al Mucciarone, 61, from Short Hills, New Jersey, agreed.

    "We come here to celebrate Jesus. This is a very important town. Great things come from small events. The son of God was born in this small village. We hope all will follow Jesus," he said.

    Audra Kasparian, 45, from Salt Lake City, Utah, called her visit to Bethlehem "a life event to cherish forever. It is one of those events that is great to be a part of."

    Palestinian President Mahmoud Abbas also visited Bethlehem and said "peace will prevail from the birthplace of Jesus, and we wish everyone peace and happiness," according to the official Palestinian Wafa news agency.

    Israeli Prime Minister Benjamin Netanyahu issued a special Christmas greeting too, wishing Christians "a year of security, prosperity and peace."

    Christmas is the high point of the year in Bethlehem, which, like the rest of the West Bank, is struggling to recover from the economic hard times that followed the violent Palestinian uprising against Israel that broke out in late 2000.

    Tourists and pilgrims who were scared away by the fighting have been returning in larger numbers. Last year's Christmas Eve celebration produced the highest turnout in more than a decade, with some 100,000 visitors, including foreign workers and Arab Christians from Israel.

    The Israeli Tourism Ministry predicted a 25 percent drop from that level this year, following last month's clash between Israel and Palestinian militants in Gaza, which put a chill on tourist arrivals. Foreign tourists heading to Bethlehem must pass through Israel or the Israel-controlled border crossing into the West Bank from Jordan.

    Outside the town's quaint Manger Square, Bethlehem is a drab, sprawling town with a dwindling Christian base - a far cry from the pastoral village of biblical times.

    About 22,000 Palestinians live in Bethlehem, according to the town council, but combined with several surrounding communities has a population of some 50,000 people.

    Overall, there are only about 50,000 Christians in the West Bank, less than 3 percent of the population, the result of a lower birthrate and increased emigration. Bethlehem's Christians make up only a third of its residents, down from 75 percent a few decades ago.

    Elias Joha, a 44-year-old Christian who runs a souvenir store, said even with the U.N. recognition, this year's celebrations were sad for him. He said most of his family has left, and that if he had the opportunity, he would do the same.

    "These celebrations are not even for Christians because there are no Christians. It is going from bad to worse from all sides ... we are not enjoying Christmas as before."

    Located on the southeastern outskirts of Jerusalem, Bethlehem has the highest unemployment in the West Bank, but the tourist boom of Christmas offered a brief reprieve. Officials say all 34 hotels in the town are fully booked for the Christmas season, including 13 new ones built this year.

    Israel turned Bethlehem over to Palestinian civil control a few days before Christmas in 1995, and since then, residents have been celebrating the holiday regardless of their religion. Many Muslims took part in celebration Monday as well.

    Christians across the region marked the holiday.

    In Iraq, Christians gathered for services with tight security, including at Baghdad's Our Lady of Salvation church, the scene of a brutal October 2010 attack that killed more than 50 worshippers and wounded scores more.

    Earlier this month, Cardinal Leonardo Sandri, who is responsible for the Vatican's outreach to the Middle East's Catholic communities, traveled to Iraq and presided over a Mass to rededicate the church following renovations. In his homily, he remembered those who were killed and expressed hope that "the tears shed in this sacred place become the good seed of communion and witness and bear much fruit," according to an account by Vatican Radio.

    The exact number of Christians remaining in Iraq is not known, but it has fallen sharply from as many as 1.4 million before the U.S.-led invasion nearly a decade ago to about 400,000 to 600,000, according community leaders cited by the U.S. State Department.

    In the Vatican, Pope Benedict XVI lit a Christmas peace candle set on the windowsill of his private studio.

    Pilgrims, tourists and Romans gathered below in St. Peter's Square for the inauguration Monday evening of a Nativity scene and cheered when the flame was lit.

    Later, the pope led Christmas Eve Mass in St. Peter's Basilica, prayed that Israelis and Palestinians live in peace and freedom, and asked the faithful to pray for strife-torn Syria as well as Lebanon and Iraq.

    The ceremony began at 10 p.m. local time Monday with the blare of trumpets, meant to symbolize Christian joy over the news of Christ's birth in Bethlehem. The basilica's main bell tolled outside, and the sweet voices of the Vatican's boys' choir wafted across the packed venue.

    Christmas Eve Mass at the Vatican traditionally began at midnight, but the start time was moved up years ago so as to give the 85-year-old pontiff more time to rest before his Christmas Day speech. That address is to be delivered at midday Tuesday from the basilica's central balcony.

    ____

    Associated Press writer Adam Schreck in Baghdad and Frances D'Emilio in Vatican City contributed..

    Associated Press

    Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-12-24-Holy%20Land-Christmas/id-e83ab5971b6b4edaa58b85783e8fc922

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